BioGem Blog

Synthesis is a step-by-step process of constructing complex molecules using a set of molecules and specific reagents. While retrosynthesis (retro- backwards) is the process of deconstructing a molecule into readily available simple molecules. IBM RXN is the first, FREE artificial intelligence (AI) web service for predicting reactions and retrosynthesis molecules. Moreover, the AI model is independent of atom-mapping and give back a confidence level of the prediction. In this tutorial, I have explained synthesis and retrosynthesis of a molecule using IBM RXN. List of resources used in this video tutorial are IBM RXN , and NCBI PubChem .

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the strain of coronavirus that causes coronavirus disease 2019 (COVID-19). It causes gene mutation in itself and the host organism, through receptor binding domain (RBD) and human angiotensin-converting enzyme 2 (ACE2) complex. The mutation level increase when it transmitted to other organisms. Gene diversity of the SARS-CoV-2 can found by constructing a phylogenetic tree through multiple sequence alignment of genome sequences. This tutorial helps you to find the current gene diversity of SARS-CoV-2.